Osteoimmunology: cytokines and the skeletal system
نویسندگان
چکیده
منابع مشابه
Osteoimmunology: cytokines and the skeletal system.
It has become clear that complex interactions underlie the relationship between the skeletal and immune systems. This is particularly true for the development of immune cells in the bone marrow as well as the functions of bone cells in skeletal homeostasis and pathologies. Because these two disciplines developed independently, investigators with an interest in either often do not fully apprecia...
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Bone and immune system are functionally interconnected. Immune and bone cells derive from same progenitors in the bone marrow, they share a common microenvironment and are being influenced by similar mediators. The evidence on increased bone resorption associated with inappropriate activation of T cells such as during inflammation, is well established. However, the molecular mechanisms beyond t...
متن کاملOsteoimmunology: interactions of the immune and skeletal systems.
Bone is a dynamic tissue that provides mechanical support, physical protection, and enables movement. Bone also serves as a storage site for minerals and is where blood cells are produced. Bone homeostasis is regulated by the balance between bone formation and resorption, and involves the coordinated action of osteoblasts and osteoclasts. Osteoblasts are bone-forming cells that secrete organic ...
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1 Department of BasicMedical Sciences, Neuroscience and Sense Organs, Section of Human Anatomy andHistology, University of Bari, 70124 Bari, Italy 2 Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy 3 Department of Medical Sciences, University of Torino, 10126 Torino, Italy 4Department of Orthopedics, Washington University School of Medicine, St. Louis,...
متن کاملOsteoimmunology: interactions of the bone and immune system.
Bone and the immune system are both complex tissues that respectively regulate the skeleton and the body's response to invading pathogens. It has now become clear that these organ systems often interact in their function. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. Because these two disciplines develo...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2008
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2008.41.7.495